ZWINT
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Template:Cs1 config Template:Short description An Error has occurred retrieving Wikidata item for infobox ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.[1]
Function
Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[1]
Interactions
ZWINT has been shown to interact with MIS12.[2][3] ZWINT has also been shown to interact with RAB3C[4]
References
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- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: ZWINT ZW10 interactor".
- ^ Page Module:Citation/CS1/styles.css has no content.Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
- ^ Page Module:Citation/CS1/styles.css has no content.Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
- ^ Page Module:Citation/CS1/styles.css has no content.van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232. S2CID 30206840.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Page Module:Citation/CS1/styles.css has no content.Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Page Module:Citation/CS1/styles.css has no content.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Page Module:Citation/CS1/styles.css has no content.Starr DA, Saffery R, Li Z, Simpson AE, Choo KH, Yen TJ, Goldberg ML (Jun 2000). "HZwint-1, a novel human kinetochore component that interacts with HZW10". Journal of Cell Science. 113 ( Pt 11) (11): 1939–50. doi:10.1242/jcs.113.11.1939. PMID 10806105.
- Page Module:Citation/CS1/styles.css has no content.Musio A, Mariani T, Montagna C, Zambroni D, Ascoli C, Ried T, Vezzoni P (Apr 2004). "Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes". Gene. 331: 33–40. doi:10.1016/j.gene.2004.01.028. PMID 15094189.
- Page Module:Citation/CS1/styles.css has no content.Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
- Page Module:Citation/CS1/styles.css has no content.Wang H, Hu X, Ding X, Dou Z, Yang Z, Shaw AW, Teng M, Cleveland DW, Goldberg ML, Niu L, Yao X (Dec 2004). "Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling". The Journal of Biological Chemistry. 279 (52): 54590–8. doi:10.1074/jbc.M407588200. PMID 15485811.
- Page Module:Citation/CS1/styles.css has no content.Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
- Page Module:Citation/CS1/styles.css has no content.Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC (Jan 2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". The Journal of Biological Chemistry. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
- Page Module:Citation/CS1/styles.css has no content.Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland DW (Apr 2005). "ZW10 links mitotic checkpoint signaling to the structural kinetochore". The Journal of Cell Biology. 169 (1): 49–60. doi:10.1083/jcb.200411118. PMC 1351127. PMID 15824131.
- Page Module:Citation/CS1/styles.css has no content.Lin YT, Chen Y, Wu G, Lee WH (Nov 2006). "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control". Oncogene. 25 (52): 6901–14. doi:10.1038/sj.onc.1209687. PMID 16732327. S2CID 11176319.
External links
- ZWINT human gene location in the UCSC Genome Browser.
- ZWINT human gene details in the UCSC Genome Browser.
