Salsoline
Page Module:Message box/ambox.css has no content.
This article needs additional citations for verification. (November 2021) |
Page Template:Chembox/styles.css has no content.
Template:Chembox IndexlistTemplate:Chembox CompToxTemplate:Chembox OHS (set)Template:Chembox Datapage check| Lua error in package.lua at line 80: module 'Module:InfoboxImage/data' not found. (±)-Salsoline
| |
| Names | |
|---|---|
| IUPAC name
6-Hydroxy-7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
| |
| Identifiers | |
Page Template:Plainlist/styles.css has no content.
| |
3D model (JSmol)
|
Page Template:Plainlist/styles.css has no content.
|
| ChEBI | Page Template:Plainlist/styles.css has no content.
|
| ChEMBL | Page Template:Plainlist/styles.css has no content.
|
| ChemSpider | Page Template:Plainlist/styles.css has no content. |
| EC Number | Page Template:Plainlist/styles.css has no content. |
| KEGG | Page Template:Plainlist/styles.css has no content.
|
PubChem CID
|
Page Template:Plainlist/styles.css has no content. |
| RTECS number | Page Template:Plainlist/styles.css has no content. |
| UNII | Page Template:Plainlist/styles.css has no content.
|
| |
| |
| Properties | |
| C11H15NO2 | |
| Molar mass | 193.246 g·mol−1 |
| Appearance | White or almost white crystalline powder |
| Density | 1.106 g/cm3 |
| Melting point | 217-219 °C |
| Solubility | Soluble in chloroform; slightly soluble in water, benzene |
| Hazards | |
| Flash point | 157.4 °C (315.3 °F; 430.5 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Template:Chembox Footer/trackingTemplate:Short description
Salsoline is a tetrahydroisoquinoline alkaloid found in some plants of the genus Salsola. Salsoline is the monomethylated metabolite of salsolinol which has been thought to contribute to Parkinson's disease.[medical citation needed] Also, this has been tied to the neuropathology of chronic alcoholism.[1]
Related compounds
Some examples of compounds that are similar to salsoline include salsolinol, isosalsoline, norsalsolinol, and carboxysalsolinol.
Reactions
These types of compounds are able to undergo addition reactions in which additions can happen to the nitrogenous ring.[citation needed] Also, it is possible for the ring to break open. In the presence of NaBH4 or H2SO4, this structure may be able to undergo carbonyl chemistry,[dubious – discuss] if present, and other reactions, such as substitution. Salsoline is a derivative of dopamine,[2] meaning it is able to function in the brain like dopamine.[medical citation needed]
Medicine
Salsoline has been detected in areas of the brain that are highest in concentration with dopamine. It has been found in the frontal cortex, basal ganglia, and hypothalamus.[2] However, there are two enantiomers, (R) and (S), and are not treated similarly in this case. The (R) and (S) enantiomers are abundant in human plasma,[citation needed] but these configurations are recognized by different machinery in the cell. Parkinson's disease is a neurotoxic disease in which the concentration of this compound is significantly increased in the cerebrospinal fluid.[citation needed] Therefore, the patients who are diagnosed with Parkinson's disease are likely found to have had these derivatives present.[citation needed]
In lab, it has become increasingly popular to try and protect the neurons from such an environment. The derivative is able to be synthesized in areas of the brain, and it is possible to now try and target these areas to influence against the build up of these toxins. Studies have shown that high levels of salsoline increase concentrations of cerebrospinal fluid in alcoholic patients.[<span title="Script error: No such module "decodeEncode".">clarification needed] It has been noted that there has been a build up of salsoline in fluid in the case of Parkinson's Disease. There are several sources that have pointed toward the conclusion that salsoline has been linked with alcoholism and intoxication.[1]
See also
References
Page Template:Reflist/styles.css has no content.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Borg, S.; Kvande, H.; Magnuson, E.; Sjöqvist, B. (October 1980). "Salsolinol and Salsoline in Cerebrospinal Lumbar Fluid of Alcoholic Patients". Acta Psychiatrica Scandinavica. 62: 171–177. doi:10.1111/j.1600-0447.1980.tb08064.x. PMID 6935920. S2CID 33979452.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Mravec, B. (2006). "Salsolinol, a Derivate of Dopamine, is a Possible Modulator of Catecholaminergic Transmission: a Review of Recent Developments" (PDF). Physiological Research. 55 (4): 353–364. doi:10.33549/physiolres.930810. PMID 16238467. S2CID 6553503.
Lua error in package.lua at line 80: module 'Module:Navbox/configuration' not found.
