Statine
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| IUPAC name
(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid
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3D model (JSmol)
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| Abbreviations | AHMHA, Sta |
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PubChem CID
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| Properties | |
| C8H17NO3 | |
| Molar mass | 175.228 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Template:Chembox Footer/trackingTemplate:Short description
Statine is a gamma amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.[1] It is thought to be responsible for the inhibitory activity of pepstatin because it mimics the tetrahedral transition state of peptide catalysis.[2]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Umezawa, H.; Aoyagi, T.; Morishima, H.; Matsuzaki, M.; Hamada, M.; Takeuchi, T. (1970). "Pepstatin, a new pepsin inhibitor produced by Actinomycetes". The Journal of Antibiotics. 23 (5): 259–262. doi:10.7164/antibiotics.23.259. PMID 4912600.
- ^ Page Module:Citation/CS1/styles.css has no content.Marciniszyn Jr, J.; Hartsuck, J. A.; Tang, J. (1976). "Mode of inhibition of acid proteases by pepstatin". The Journal of Biological Chemistry. 251 (22): 7088–7094. doi:10.1016/S0021-9258(17)32945-9. PMID 993206.